The following are the zip codes in the municipalities and cities of Negros Oriental.
| Region | Provinces | City/Municipality | Zip Code |
| NIR (Negros Island Region) | Negros Oriental | Amian | 6203 |
| NIR (Negros Island Region) | Negros Oriental | Ayungon | 6210 |
| NIR (Negros Island Region) | Negros Oriental | Bacung | 6216 |
| NIR (Negros Island Region) | Negros Oriental | Bais City | 6206 |
| NIR (Negros Island Region) | Negros Oriental | Basay | 6222 |
| NIR (Negros Island Region) | Negros Oriental | Bayawan | 6221 |
| NIR (Negros Island Region) | Negros Oriental | Bindoy | 6209 |
| NIR (Negros Island Region) | Negros Oriental | Canlaon City | 6223 |
| NIR (Negros Island Region) | Negros Oriental | Dauin | 6217 |
| NIR (Negros Island Region) | Negros Oriental | Dumaguete City | 6200 |
| NIR (Negros Island Region) | Negros Oriental | Guihulngan | 6214 |
| NIR (Negros Island Region) | Negros Oriental | Jimalalud | 6212 |
| NIR (Negros Island Region) | Negros Oriental | La Libertad | 6213 |
| NIR (Negros Island Region) | Negros Oriental | Mabinay | 6208 |
| NIR (Negros Island Region) | Negros Oriental | Manjuyod | 6208 |
| NIR (Negros Island Region) | Negros Oriental | Pamplona | 6205 |
| NIR (Negros Island Region) | Negros Oriental | San Jose | 6202 |
| NIR (Negros Island Region) | Negros Oriental | Siaton | 6219 |
| NIR (Negros Island Region) | Negros Oriental | Sibulan | 6201 |
| NIR (Negros Island Region) | Negros Oriental | Sta. Catalina | 6220 |
| NIR (Negros Island Region) | Negros Oriental | Tanjay | 6204 |
| NIR (Negros Island Region) | Negros Oriental | Tayasan | 6211 |
| NIR (Negros Island Region) | Negros Oriental | Valencia | 6215 |
| NIR (Negros Island Region) | Negros Oriental | Valle Hermoso | 6224 |
| NIR (Negros Island Region) | Negros Oriental | Zamboanguita | 6218 |
